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General keno guidelines suggest making selections with between four and eight numbers. That means your keno odds will range between 1 in 327 for getting four out of four, and 1 in 230,115 for getting eight out of eight.
If you want to make serious money you need to bet 5, 6, or 7 spots. There's still no guarantee but that's your best chance. Also you might try video keno.